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持續(xù)近兩個多月的新型冠狀病毒感染的肺炎疫情牽動著每一個人的心，為了打贏這場疫情防控狙擊戰(zhàn)，搞清致病機理，研發(fā)抗病毒藥物和疫苗刻不容緩。Jena bioscience品牌有豐富的抗病毒核苷酸/核苷酸類似物，助力抗病毒藥物研發(fā)。
抗病毒核苷及核苷酸類似物主要有:
抗病毒核苷/核苷酸類似物可以通過抑制病毒復制的幾個關鍵過程來抑制病毒繁殖，它們通過與天然的dNTP/NTP競爭結(jié)合到新的病毒核酸中，從而導致鏈終止或者誘變。在細胞培養(yǎng)實驗中，可以用抗病毒核苷酸的非磷酸化核苷變體，這種核苷酸在細胞內(nèi)被多種病毒和/或宿主激酶激活，從而發(fā)揮(tri)磷酸化形式的抗病毒作用。
熱銷抗病毒核苷/核苷酸類似物：
|
品牌 |
貨號 |
品名 |
規(guī)格 |
|
Jena Bioscience |
NU-1605S |
3TCMP |
10 μl (10 mM) |
|
Jena Bioscience |
NU-1605L |
3TCMP |
5 x 10 μl (10 mM) |
|
Jena Bioscience |
NU-1606S |
3TCTP |
5 μl (10 mM) |
|
Jena Bioscience |
NU-1606L |
3TCTP |
5 x 5 μl (10 mM) |
|
Jena Bioscience |
NU-1603S |
d4TMP |
20 μl (10 mM) |
|
Jena Bioscience |
NU-1603L |
d4TMP |
5 x 20 μl (10 mM) |
|
Jena Bioscience |
NU-1601S |
AzTMP |
20 μl (10 mM) |
|
Jena Bioscience |
NU-1601L |
AzTMP |
5 x 20 μl (10 mM) |
|
Jena Bioscience |
NU-989S |
AzTTP |
10 μl (100 mM) |
|
Jena Bioscience |
NU-989L |
AzTTP |
5 x 10 μl (100 mM) |
|
Jena Bioscience |
NU-875 |
ara-Adenosine-5'-monophosphate (ara-AMP) |
2 mg |
|
Jena Bioscience |
NU-1111S |
50 μl (10 mM) |
|
|
Jena Bioscience |
NU-1111L |
ara-Adenosine-5'-triphosphate (ara-ATP) |
5 x 50 μl (10 mM) |
|
Jena Bioscience |
NU-876 |
Acyclovir-5'-monophosphate |
2 mg |
|
Jena Bioscience |
NU-877 |
Acyclovir-5'-triphosphate |
2 mg |
|
Jena Bioscience |
NU-021-2 |
Ribavirin-5'-monophosphate |
2 mg |
|
Jena Bioscience |
NU-1105S |
20 μl (10 mM) |
|
|
Jena Bioscience |
NU-1105L |
Ribavirin-triphosphate |
5 x 20 μl (10 mM) |
|
Jena Bioscience |
N-DN-8234-100 |
β-L-2'-Deoxythymidine |
100 mg |
|
Jena Bioscience |
NU-896S |
10 μl (100 mM) |
|
|
Jena Bioscience |
NU-896L |
6-Aza-UTP |
5 x 10 μl (100 mM) |
|
Jena Bioscience |
NU-974 |
Tenofovir |
100 mg |
|
Jena Bioscience |
NU-975 |
Tenofovir-diphosphate |
1 mg |
|
Jena Bioscience |
NU-989S |
10 μl (100 mM) |
|
|
Jena Bioscience |
NU-989L |
AzTTP |
5 x 10 μl (100 mM) |
|
Jena Bioscience |
NU-275S |
10 μl |
|
|
Jena Bioscience |
NU-275L |
Ganciclovir-triphosphate |
5 x 10 μl |
西美杰是Jena bioscience中國總代理，為用戶提供完善的技術與售后服務。如對產(chǎn)品感興趣歡迎撥打西美杰客服熱線400-050-4006了解詳細信息。西美杰會更好的協(xié)助科研工作者的實驗工作，支持全國戰(zhàn)“疫”，早日戰(zhàn)勝病毒。武漢加油！中國加油！
參考文獻：
1] Huang at al. (2011) Effect of reverse transcriptase inhibitors on Line-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochemistry 12:18.
[2] Vaccaro at al. (1999) Mechanism of Inhibition of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by d4TTP: an Equivalent Incorporation Efficiency Relative to the Natural Substrate dTTP. Antimicrob. Agents Chemother. 44 (1):217.
[3] Jaju at al. (1995) Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. J. Biol. Chem. 270 (17):9740.
[4] Furmann at al. (1979) Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl)guanine and Its Triphosphate. J. Virol. 29 (2):154.
[5] Muller at al. (1977) Inhibition of Herpesvirus DNA synthesis by 9-O-D-Arabinofuranosyladenine in cellular and cell-free systems. Ann. N.Y. Acad. Sci. 284:34.
[6] Crotty at al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nature Medicine 6 (12):1375.
[7] Ray at al. (2009) Metabolism of antiviral nucleosides and nucleotides. In: Antiviral Research: Strategies in antiviral drug discovery (LaFemina). ASM Press.
[8] Simons at al. (2005) Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics. Current Topics in Medicinal Chemistry 5:1191.
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